Scientists Probe New Link Between Gut Health and Chronic Disease

What would happen if you could turn an unhealthy gut microbiome into a healthy one? According to research recently conducted at Scripps Research Institute, doing so may improve cholesterol levels and stave off chronic disease. According to this new research, gut health and disease are linked, suggesting improving gut health can positively impact the risks of developing certain diseases.

Recent Study Links Gut Health and Disease

A recent research project used particles called peptides to identify how introducing certain molecules into the gut microbiome affected cholesterol levels in the body. Using mice that were fed high-fat diets and bred to develop arterial plaque, the team used peptides to alter the health of the gut microbiome and, in turn, improve cholesterol levels.

An unhealthy gut microbiome is one that does not contain a diverse selection of bacteria, so the goal was to encourage more diverse bacterial growth in the gut microbiome. They did this by introducing specific peptides, which would cause different strains of bacteria to thrive in the guts of the test mice. In this way, they were able to transform an unhealthy gut microbiome into a healthy one.

Before and after administering the peptides, the researchers conducted tests to evaluate the health of the mice. This involved taking fecal samples and looking at arterial health, while also examining molecules that indicate higher risks for developing inflammation, inhibited immunity and poor metabolic rates. They found that there was a 50 percent drop in plasma cholesterol in the mice receiving the peptide treatments. At the same time, researchers could not find a significant amount of plaque in the arteries of the same test mice.

While the research was conducted on mice, the researchers hope it will lead the way toward developing better treatments for human patients. Particularly, the research linking gut health and disease shows promise in treating people suffering from atherosclerosis and cardiovascular disease, though additional research is needed. Future research may take a deeper focus on how altering the gut microbiome can lower the risks of developing other diseases.

Can Strengthening the Gut Microbiome Stave Off Disease?

Another recent study found that a diverse gut microbiome can affect HDL (good) cholesterol levels, triglycerides and the likelihood of developing obesity. To look at this relationship, researchers examined the fecal samples from 893 subjects, ranging in ages from 18 to 80. The samples helped the scientists determine the richness of bacteria in the gut microbiome and the diversity of the types of bacteria. Those results were compared against the lipid levels and body mass index measurements of the subjects.

Once the comparisons were complete, they found that there were 34 types of bacteria that were positively associated with HDL cholesterol and triglyceride levels. They also find a negative correlation between the presence of those particular bacteria and BMI measurements of the subjects.

The newly discovered link between gut health and disease, which was confirmed in this study, suggests that the gut microbiome plays an important roles in several areas of health. In addition to promoting better arterial and cardiovascular health, maintaining a healthy gut microbiome can help reduce unhealthy dietary cravings and may even affect the BMI of an individual. The researchers hopes future studies will strengthen the evidence that the gut microbiome plays a vital role in human health, so those findings can be used to develop more natural treatments for certain diseases.

Natural Ways to Bolster Your Gut Microbiome

Add Prebiotics and Probiotics to Your Diet

There are two primary ways to ensure you're introducing sufficient quantities of probiotics and prebiotics into your gut microbiome. Many high-quality dietary supplements on the market incorporate both prebiotics and probiotics to maximize gut health. Additionally, you can eat foods that are excellent sources of prebiotics and probiotics. While there are many food sources of these important substances, a few are listed here to get you started.

Prebiotic Foods

• artichokes
• cucumbers
• asparagus
• apples
• berries
• bananas
• honey
• dark chocolate
• seeds (flax, hemp, pumpkin, chia)

Probiotic Foods

• sauerkraut
• pickles
• kimchi
• plain yogurt
• other fermented foods

Reduce Your Sugar Intake

Maintaining a healthy gut microbiome has as much to do with what you don't eat as it does with what you do consume. Consuming foods and drinks rich in refined sugar actually prevent the bacteria in your gut from getting the nourishment they need. As a result, some of the helpful bacteria in your gut will eventually die off, leaving you with a less diverse microbiome.

Intermittent Fasting

Fasting for brief periods can give your gut the time it needs to heal. It can also help strengthen your immune system by restoring the bacterial balance in the gut. As you fast, you should be drinking plenty of water. To add a bit of flavor, you can use lemons or apple cider vinegar. Adding bone broth to your fast can also be helpful, since the gelatin and amino acids in the broth have been shown to help the gut lining heal and grow stronger.

Get Back to Nature

Improving the diversity of your gut microbiome doesn't just concern your diet. Getting enough exercise can help, especially if you're doing it outside. Walking barefoot in nature or simply breathing the fresh air can expose you to a broad range of types of bacteria. Additionally, buy your produce from organic farms and give them a slight rinse to ensure you don't wash away the bacteria. Since each living thing plays host to a different selection of bacteria, spending time among a variety of plants and animals can help you strengthen your gut microbiome.